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Nintendo DS "M" Games
- Madagascar
- Madden NFL 06
- Madden NFL 07
- Madden NFL 08
- Madden NFL 09
- Madden NFL 2005
- Mage Knight: Destiny's Soldier
- Magical Starsign
- Magnetica
- Mah Jong Quest: Expeditions
- Major League Baseball 2K6
- Major League Baseball 2K7
- Major League Baseball 2K8 Fantasy All-Stars
- Mario & Luigi: Partners in Time
- Mario & Sonic at the Olympic Games
- Mario Hoops 3 on 3
- Mario Kart DS
- Mario Party DS
- Mario vs. Donkey Kong 2: March of the Minis
- Marvel Nemesis: Rise of the Imperfects
- Marvel Trading Card Game
- Marvel: Ultimate Alliance
- Math Play
- Mazes of Fate 2
- MechAssault: Phantom War
- Mega Brain Boost
- Mega Man Battle Network 5: Double Team DS
- Mega Man Star Force: Leo
- Mega Man Star Force: Pegasus
- Mega Man ZX
- Mega Man ZX Advent
- Meteos
- Meteos: Disney Magic
- Metroid Prime Pinball
- Metroid Prime: Hunters
- Miami Nights: Singles in the City
- Micro Machines V4
- Mind Quiz: Your Brain Coach
- Mini RC Rally
- Miss Spider's: Harvest Time Hop & Fly
- Monopoly Boggle Yahtzee Battleship
- Monster Bomber
- Monster House
- Monster Jam
- Monster Lab
- Monster Trucks DS
- Mr. Driller: Drill Spirits
- Mr. Slime
- Mushroom Men
- MX vs ATV Untamed
- My French Coach
- My Frogger: Toy Trials
- My Horse & Me
- My Little Flufties
- My Spanish Coach
- My Word Coach
- MySims
- Myst
- Mysterious Dungeon: Shiren the Wanderer
- Mystery Dungeon: Shiren the Wanderer